There are
864 mi
from Lubbock, TX to Sikeston, MO
That's the driving distance. It would take 15 hours 44 mins to go from Lubbock, Texas to Sikeston, Missouri.
The flight distance (direct flight from Lubbock, TX to Sikeston, MO) is 728.26 mi.
864 mi = 1,390.34 kms