There are
3,127 mi
from Lowell, MA to San Mateo, CA
That's the driving distance. It would take 2 days 7 hours to go from Lowell, Massachusetts to San Mateo, California.
The flight distance (direct flight from Lowell, MA to San Mateo, CA) is 2,677.67 mi.
3,127 mi = 4.83 kms