Miles between Lowell, MA and Depew, NY

There are
449 mi
from Lowell, MA to Depew, NY

That's the driving distance. It would take 8 hours 47 mins to go from Lowell, Massachusetts to Depew, New York.

The flight distance (direct flight from Lowell, MA to Depew, NY) is 374.47 mi.

449 mi = 722.29 kms