Miles between Louisville, KY and St Charles, MO

There are
281 mi
from Louisville, KY to St Charles, MO

That's the driving distance. It would take 5 hours 17 mins to go from Louisville, Kentucky to St Charles, Missouri.

The flight distance (direct flight from Louisville, KY to St Charles, MO) is 259.58 mi.

281 mi = 452.74 kms