Miles between Louisville, KY and Sikeston, MO

There are
281 mi
from Louisville, KY to Sikeston, MO

That's the driving distance. It would take 5 hours 17 mins to go from Louisville, Kentucky to Sikeston, Missouri.

The flight distance (direct flight from Louisville, KY to Sikeston, MO) is 230.24 mi.

281 mi = 451.58 kms