There are
792 mi
from Louisville, KY to Poughkeepsie, NY
That's the driving distance. It would take 15 hours 5 mins to go from Louisville, Kentucky to Poughkeepsie, New York.
The flight distance (direct flight from Louisville, KY to Poughkeepsie, NY) is 669.79 mi.
792 mi = 1,275.03 kms