There are
603 mi
from Lorain, OH to Cape Girardeau, MO
That's the driving distance. It would take 11 hours 32 mins to go from Lorain, Ohio to Cape Girardeau, Missouri.
The flight distance (direct flight from Lorain, OH to Cape Girardeau, MO) is 485.08 mi.
603 mi = 971.16 kms