There are
948 mi
from Lexington, KY to Sioux Falls, SD
That's the driving distance. It would take 17 hours 5 mins to go from Lexington, Kentucky to Sioux Falls, South Dakota.
The flight distance (direct flight from Lexington, KY to Sioux Falls, SD) is 741.78 mi.
948 mi = 1,525.07 kms