There are
2,409 mi
from Lexington, KY to San Mateo, CA
That's the driving distance. It would take 1 day 18 hours to go from Lexington, Kentucky to San Mateo, California.
The flight distance (direct flight from Lexington, KY to San Mateo, CA) is 2,050.64 mi.
2,409 mi = 3.22 kms