There are
531 mi
from Lexington, KY to North Tonawanda, NY
That's the driving distance. It would take 10 hours 15 mins to go from Lexington, Kentucky to North Tonawanda, New York.
The flight distance (direct flight from Lexington, KY to North Tonawanda, NY) is 454.68 mi.
531 mi = 854.08 kms