There are
538 mi
from Lexington, KY to Niagara Falls, NY
That's the driving distance. It would take 10 hours 26 mins to go from Lexington, Kentucky to Niagara Falls, New York.
The flight distance (direct flight from Lexington, KY to Niagara Falls, NY) is 451.80 mi.
538 mi = 865.47 kms