There are
626 mi
from Lexington, KY to Neosho, MO
That's the driving distance. It would take 11 hours 39 mins to go from Lexington, Kentucky to Neosho, Missouri.
The flight distance (direct flight from Lexington, KY to Neosho, MO) is 546.79 mi.
626 mi = 1,007.72 kms