There are
661 mi
from Lexington, KY to La Crosse, WI
That's the driving distance. It would take 12 hours 28 mins to go from Lexington, Kentucky to La Crosse, Wisconsin.
The flight distance (direct flight from Lexington, KY to La Crosse, WI) is 530.75 mi.
661 mi = 1,063.23 kms