There are
657 mi
from Lexington, KY to Ithaca, NY
That's the driving distance. It would take 12 hours 40 mins to go from Lexington, Kentucky to Ithaca, New York.
The flight distance (direct flight from Lexington, KY to Ithaca, NY) is 519.87 mi.
657 mi = 1,057.59 kms