There are
453 mi
from Lexington, KY to Hannibal, MO
That's the driving distance. It would take 8 hours 35 mins to go from Lexington, Kentucky to Hannibal, Missouri.
The flight distance (direct flight from Lexington, KY to Hannibal, MO) is 386.19 mi.
453 mi = 729.11 kms