There are
350 mi
from Lexington, KY to Florissant, MO
That's the driving distance. It would take 6 hours 36 mins to go from Lexington, Kentucky to Florissant, Missouri.
The flight distance (direct flight from Lexington, KY to Florissant, MO) is 319.18 mi.
350 mi = 563.48 kms