There are
664 mi
from Lexington, KY to Des Moines, IA
That's the driving distance. It would take 12 hours 6 mins to go from Lexington, Kentucky to Des Moines, Iowa.
The flight distance (direct flight from Lexington, KY to Des Moines, IA) is 541.80 mi.
664 mi = 1,068.55 kms