There are
1,136 mi
from Las Cruces, NM to South San Francisco, CA
That's the driving distance. It would take 20 hours 25 mins to go from Las Cruces, New Mexico to South San Francisco, California.
The flight distance (direct flight from Las Cruces, NM to South San Francisco, CA) is 957.63 mi.
1,136 mi = 1.61 kms