There are
1,259 mi
from Las Cruces, NM to Sikeston, MO
That's the driving distance. It would take 21 hours 33 mins to go from Las Cruces, New Mexico to Sikeston, Missouri.
The flight distance (direct flight from Las Cruces, NM to Sikeston, MO) is 1,024.64 mi.
1,259 mi = 1.61 kms