There are
1,607 mi
from Las Cruces, NM to Greenville, SC
That's the driving distance. It would take 1 day 4 hours to go from Las Cruces, New Mexico to Greenville, South Carolina.
The flight distance (direct flight from Las Cruces, NM to Greenville, SC) is 1,410.06 mi.
1,607 mi = 1.61 kms