There are
1,645 mi
from Largo, FL to Sioux Falls, SD
That's the driving distance. It would take 1 day 6 hours to go from Largo, Florida to Sioux Falls, South Dakota.
The flight distance (direct flight from Largo, FL to Sioux Falls, SD) is 1,328.93 mi.
1,645 mi = 1.61 kms