There are
1,036 mi
from Laredo, TX to Cape Girardeau, MO
That's the driving distance. It would take 18 hours 3 mins to go from Laredo, Texas to Cape Girardeau, Missouri.
The flight distance (direct flight from Laredo, TX to Cape Girardeau, MO) is 892.14 mi.
1,036 mi = 1.61 kms