There are
1,478 mi
from Lansdale, PA to Mesquite, TX
That's the driving distance. It would take 1 day 2 hours to go from Lansdale, Pennsylvania to Mesquite, Texas.
The flight distance (direct flight from Lansdale, PA to Mesquite, TX) is 1,287.29 mi.
1,478 mi = 2,378.35 kms