There are
1,346 mi
from Lancaster, SC to Sioux Falls, SD
That's the driving distance. It would take 1 day 1 hour to go from Lancaster, South Carolina to Sioux Falls, South Dakota.
The flight distance (direct flight from Lancaster, SC to Sioux Falls, SD) is 1,046.33 mi.
1,346 mi = 2,165.58 kms