Miles between Lancaster, SC and Sikeston, MO

There are
628 mi
from Lancaster, SC to Sikeston, MO

That's the driving distance. It would take 12 hours 14 mins to go from Lancaster, South Carolina to Sikeston, Missouri.

The flight distance (direct flight from Lancaster, SC to Sikeston, MO) is 515.85 mi.

628 mi = 1,011.05 kms