There are
1,860 mi
from Lancaster, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 8 hours to go from Lancaster, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Lancaster, CA to Cape Girardeau, MO) is 1,604.78 mi.
1,860 mi = 2,993.68 kms