There are
1,330 mi
from Lakewood, CO to Picayune, MS
That's the driving distance. It would take 1 day to go from Lakewood, Colorado to Picayune, Mississippi.
The flight distance (direct flight from Lakewood, CO to Picayune, MS) is 1,074.43 mi.
1,330 mi = 2,139.86 kms