There are
957 mi
from Lakewood, CO to Cape Girardeau, MO
That's the driving distance. It would take 17 hours 1 min to go from Lakewood, Colorado to Cape Girardeau, Missouri.
The flight distance (direct flight from Lakewood, CO to Cape Girardeau, MO) is 856.47 mi.
957 mi = 1,539.80 kms