There are
901 mi
from Lakeland, FL to Cape Girardeau, MO
That's the driving distance. It would take 17 hours 7 mins to go from Lakeland, Florida to Cape Girardeau, Missouri.
The flight distance (direct flight from Lakeland, FL to Cape Girardeau, MO) is 776.30 mi.
901 mi = 1,449.76 kms