There are
2,415 mi
from La Mesa, CA to Zephyrhills, FL
That's the driving distance. It would take 1 day 18 hours to go from La Mesa, California to Zephyrhills, Florida.
The flight distance (direct flight from La Mesa, CA to Zephyrhills, FL) is 2,088.28 mi.
2,415 mi = 3,887.10 kms