There are
1,757 mi
from La Mesa, CA to Yazoo City, MS
That's the driving distance. It would take 1 day 6 hours to go from La Mesa, California to Yazoo City, Mississippi.
The flight distance (direct flight from La Mesa, CA to Yazoo City, MS) is 1,541.54 mi.
1,757 mi = 2,827.90 kms