There are
2,460 mi
from La Mesa, CA to Titusville, FL
That's the driving distance. It would take 1 day 18 hours to go from La Mesa, California to Titusville, Florida.
The flight distance (direct flight from La Mesa, CA to Titusville, FL) is 2,160.36 mi.
2,460 mi = 3,959.39 kms