There are
2,448 mi
from La Mesa, CA to Roanoke, VA
That's the driving distance. It would take 1 day 18 hours to go from La Mesa, California to Roanoke, Virginia.
The flight distance (direct flight from La Mesa, CA to Roanoke, VA) is 2,107.60 mi.
2,448 mi = 3,939.95 kms