There are
2,173 mi
from La Mesa, CA to Lexington, KY
That's the driving distance. It would take 1 day 14 hours to go from La Mesa, California to Lexington, Kentucky.
The flight distance (direct flight from La Mesa, CA to Lexington, KY) is 1,857.41 mi.
2,173 mi = 3,497.72 kms