There are
1,556 mi
from La Mesa, CA to Joplin, MO
That's the driving distance. It would take 1 day 3 hours to go from La Mesa, California to Joplin, Missouri.
The flight distance (direct flight from La Mesa, CA to Joplin, MO) is 1,306.20 mi.
1,556 mi = 2,504.68 kms