There are
2,355 mi
from La Mesa, CA to Fernandina Beach, FL
That's the driving distance. It would take 1 day 17 hours to go from La Mesa, California to Fernandina Beach, Florida.
The flight distance (direct flight from La Mesa, CA to Fernandina Beach, FL) is 2,085.28 mi.
2,355 mi = 3,790.14 kms