There are
1,842 mi
from La Mesa, CA to Cahokia, IL
That's the driving distance. It would take 1 day 8 hours to go from La Mesa, California to Cahokia, Illinois.
The flight distance (direct flight from La Mesa, CA to Cahokia, IL) is 1,552.44 mi.
1,842 mi = 2,963.89 kms