There are
499 mi
from Knoxville, TN to Wyandotte, MI
That's the driving distance. It would take 9 hours 24 mins to go from Knoxville, Tennessee to Wyandotte, Michigan.
The flight distance (direct flight from Knoxville, TN to Wyandotte, MI) is 434.05 mi.
499 mi = 803.83 kms