There are
1,196 mi
from Knoxville, TN to Watertown, SD
That's the driving distance. It would take 21 hours 40 mins to go from Knoxville, Tennessee to Watertown, South Dakota.
The flight distance (direct flight from Knoxville, TN to Watertown, SD) is 926.82 mi.
1,196 mi = 1.61 kms