There are
800 mi
from Knoxville, TN to Waterloo, IA
That's the driving distance. It would take 14 hours 38 mins to go from Knoxville, Tennessee to Waterloo, Iowa.
The flight distance (direct flight from Knoxville, TN to Waterloo, IA) is 637.26 mi.
800 mi = 1,287.95 kms