There are
601 mi
from Knoxville, TN to Sycamore, IL
That's the driving distance. It would take 11 hours 21 mins to go from Knoxville, Tennessee to Sycamore, Illinois.
The flight distance (direct flight from Knoxville, TN to Sycamore, IL) is 488.70 mi.
601 mi = 967.02 kms