There are
1,011 mi
from Knoxville, TN to South Sioux City, NE
That's the driving distance. It would take 18 hours 41 mins to go from Knoxville, Tennessee to South Sioux City, Nebraska.
The flight distance (direct flight from Knoxville, TN to South Sioux City, NE) is 804.39 mi.
1,011 mi = 1.61 kms