There are
1,098 mi
from Knoxville, TN to Sioux Falls, SD
That's the driving distance. It would take 20 hours 5 mins to go from Knoxville, Tennessee to Sioux Falls, South Dakota.
The flight distance (direct flight from Knoxville, TN to Sioux Falls, SD) is 856.10 mi.
1,098 mi = 1.61 kms