Miles between Knoxville, TN and Sikeston, MO

There are
377 mi
from Knoxville, TN to Sikeston, MO

That's the driving distance. It would take 7 hours 2 mins to go from Knoxville, Tennessee to Sikeston, Missouri.

The flight distance (direct flight from Knoxville, TN to Sikeston, MO) is 321.33 mi.

377 mi = 607.46 kms