There are
2,524 mi
from Knoxville, TN to Shasta Lake, CA
That's the driving distance. It would take 1 day 20 hours to go from Knoxville, Tennessee to Shasta Lake, California.
The flight distance (direct flight from Knoxville, TN to Shasta Lake, CA) is 2,092.72 mi.
2,524 mi = 3.22 kms