There are
682 mi
from Knoxville, TN to Seminole, FL
That's the driving distance. It would take 12 hours 45 mins to go from Knoxville, Tennessee to Seminole, Florida.
The flight distance (direct flight from Knoxville, TN to Seminole, FL) is 564.98 mi.
682 mi = 1,096.86 kms