Miles between Knoxville, TN and Sanford, FL

There are
643 mi
from Knoxville, TN to Sanford, FL

That's the driving distance. It would take 12 hours 16 mins to go from Knoxville, Tennessee to Sanford, Florida.

The flight distance (direct flight from Knoxville, TN to Sanford, FL) is 520.61 mi.

643 mi = 1,035.47 kms