There are
2,201 mi
from Knoxville, TN to San Diego, CA
That's the driving distance. It would take 1 day 14 hours to go from Knoxville, Tennessee to San Diego, California.
The flight distance (direct flight from Knoxville, TN to San Diego, CA) is 1,900.22 mi.
2,201 mi = 3.22 kms