There are
586 mi
from Knoxville, TN to Saginaw, MI
That's the driving distance. It would take 10 hours 49 mins to go from Knoxville, Tennessee to Saginaw, Michigan.
The flight distance (direct flight from Knoxville, TN to Saginaw, MI) is 515.36 mi.
586 mi = 943.73 kms