There are
2,196 mi
from Knoxville, TN to Poway, CA
That's the driving distance. It would take 1 day 14 hours to go from Knoxville, Tennessee to Poway, California.
The flight distance (direct flight from Knoxville, TN to Poway, CA) is 1,888.78 mi.
2,196 mi = 3.22 kms